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Irini GergesMargherita TamplenizzaFederico MartelloStefano KomanGiulia Chincarini, Camilla Recordati, Mariacaterina Tamplenizza, Scott Guelcher, Maurizio Crestani & Alessandro Tocchio  “Conditioning the microenvironment for soft tissue regeneration in a cell free scaffold”. 

You can access the full-text of our paper here: https://rdcu.be/cncfX

I. Gerges, M. Tamplenizza, F. Martello, C. Recordati, C. Martelli, L. Ottobrini, M. Tamplenizza, S. A. Guelcher, A. Tocchio, C. Lenardi.  Exploring the potential of polyurethane-based soft foam as a cell-free scaffold for soft tissue regeneration. Acta Biomaterialia (2018)

E. Rossi*, I. Gerges*, A. Tocchio*, M. Tamplenizza, P. Aprile, C. Recordati, F. Martello, I. Martin, P. Milani, C. Lenardi. Biologically and mechanically driven design of an RGD-mimetic Macroporous Foam for Adipose Tissue Engineering Applications. Biomaterials (2016). (*Authors contributed equally)

C. Schulte; S. Rodighiero; M. A. Cappelluti; L. Puricelli; E. Maffioli; F. Borghi; A. Negri; E. Sogne; M. Galluzzi; C. Piazzoni; M. Tamplenizza; A. Podestà; G. Tedeschi; C. Lenardi; P. Milani. Conversion of nanoscale topographical information of cluster-assembled zirconia surfaces into mechanotransductive events promotes neuronal differentiation. J Nanobiotechnology (2016).


I. Gerges, F. Martello, M. Tamplenizza, A. TocchioPolimeri Poliuretanici Espansi per la Rigenerazione del Tessuto Connettivo, Italian Patent filing request n° MI2014A000754.

C. Lenardi, F. Martello, A. TocchioMethod For Producing Three-Dimensional Monolithic Microfluidic Devices, WIPO -PCT Patent application PCT/IB2012/052732

I. Gerges*, M. Tamplenizza*, S. Lopa, C. Recordati, F. Martello, A. Tocchio, L. Ricotti, C. Arrigoni, P. Milani, M. Moretti C. Lenardi. Creep-Resistant Dextran-Based Polyurethane Foam as a Candidate Scaffold for Bone Tissue Engineering: Synthesis, Chemico-Physical Characterization, In vitro and In vivo Biocompatibility. International Journal of Polymeric Materials (2016). (*Authors contributed equally)

I. Gerges*M. Tamplenizza*, E. Rossi*, A. TocchioF. Martello, C. Recordati, D. Kumar, N. R. Forsyth, Y. Liu and C. Lenardi. A Tailor-Made Synthetic Polymer for Cell Encapsulation: Design Rationale, Synthesis, Chemical–Physics and Biological Characterizations. Macromolecular Bioscience, 2016. (*Authors contributed equally)

T. Santaniello, Y. Yan, A. Tocchio, F. Martello, F. Gassa, P. Webb, W. Zhao, M. Tamplenizza, C. Schulte,  Y. Liu, D. Hutt, P. Milani, P. Conway, C. Lenardi. On-chip single cell funnelling operated by microfabricated thermo-responsive hydrogel layers. Journal of Micromechanics and Microengineering (2015).

A. Tocchio, F. Martello, M. Tamplenizza, E. Rossi, I. Gerges, P. Milani, C. Lenardi, RGD-mimetic poly(amidoamine) hydrogel for fabrication of complex cell-laden micro constructs, Acta Biomaterialia, 2015;18:144-5.

M. Tamplenizza*, A. Tocchio*, I. Gerges*, F. Martello, C. Martelli, L. Ottobrini, G. Lucignani, P. Milani, C. Lenardi, In-vivo imaging study of angiogenesis in a channelized porous scaffoldMol Imaging. 2015;14. (* Authors contributed equally)

T. Santaniello, · Y. Yan, · A. Tocchio, · F. Martello, · P. Milani, · C. Lenardi, A room-temperature bonding technique for the packaging of hydrogel-based hybrid microfluidic devices, Microfluid Nanofluid, 2015, DOI 10.1007/s10404-015-1544-x.

A. Tocchio, M. Tamplenizza, F. Martello, I. Gerges, E. Rossi, S. Argentiere, S. Rodighiero, W. Zhao, P. Milani, C. Lenardi. Versatile fabrication of vascularizable scaffolds for large tissue engineering in bioreactor. Biomaterials (2015).

F. Martello, A. Tocchio, M. Tamplenizza, I. Gerges, V. Pistis, R. Recenti, Monica Bortolin, M. Del Fabbro, S. Argentiere, P. Milani, C. Lenardi, Poly(amido-amine)-based hydrogels with tailored mechanical properties and degradation rates for tissue engineering, Acta Biomaterialia, 10 (2014) 1206-1215.

C. Villa, F. Martello, S. Erratico, A. Tocchio, M. Belicchi, C. Lenardi, Y. Torrente, P(NIPAAM–co-HEMA) Thermoresponsive Hydrogels: an Alternative Approach for Muscle Cell Sheet Engineering, Journal of Tissue Engineering and Regenerative Medicine, 2014, DOI: 10.1002/term.1898.

M. Tamplenizza, C. Lenardi, E. Maffiolo, S. Nonnis, A. Negri, S. Forti, E. Sogne, S. De Astis, M. Matteoli, P. Milani, G. Tedeschi, Nitric oxide synthase mediates PC12 differentiation induced by the surface topography of nanostructured TiO2. Journal of Nanobiotechnology, 2013, 11:35. DOI: 10.1186/1477-3155-11-35.

PG. Agostoni, E. Swenson, R. Fumagalli, E. Salvioni, G. Cattadori, S. Farina, M. Bussotti, M. Tamplenizza, C. Lombardi, D. Bonacina, M. Brioschi, S. Caravita, P.A. Modesti, M. Revera, A. Giuliano, P. Meriggi, A. Faini, G. Bilo, C. Banfi, G.F. Parati, Acute high altitude exposure reduces lung diffusion: Data from the HIGHCARE Alps Project. Respir Physiol Neurobiol. 2013 Aug 15;188(2):223-8. doi: 10.1016/j.resp.2013.04.005. Epub 2013 Apr 23.

F. Martello, M. Piest, J. F. J. Engbersen, P. Ferruti, Effects of branched or linear architecture of bioreducible poly(amido amine)s on their in vitro gene delivery properties. Journal of Controlled Release, 2012, 164, 372–9. 

V. Morigi, A. Tocchio, C. B. Pellegrini, J. H. Sakamoto, M. Arnone, and E. Tasciotti, Nanotechnology in Medicine: From Inception to Market Domination, Journal of Drug Delivery, Volume 2012 (2012), Article ID 389485, 7 pages.

A.V. Singh, M. Ferri, M. Tamplenizza, F. Borghi, G. Divitini, C. Ducati, C. Lenardi, C. Piazzoni, M. Merlini, A. Podestà, P. Milani, Bottom-up engineering of the surface roughness of nanostructured cubic Zirconia to control cell adhesion. Nanotechnology, 2012 Nov 30;23(47):475101. doi: 10.1088/0957-4484/23/47/475101. Epub 2012 Oct 30.

T. Santaniello, F. Martello, A. Tocchio, F. Gassa, P. Webb, P. Milani and C. Lenardi, Excimer laser micropatterning of freestanding thermo-responsive hydrogel layers for cells-on-chip applications, Journal of Micromechanics and Microengineering, 2012, 22, 105033.

S. Dossena, R. Gandini, G. Tamma, V. Vezzoli, C. Nofziger, M. Tamplenizza, E. Salvioni, E. Bernardinelli , G. Meyer , G. Valenti, M. Wolf-Watz, J. Fuerst, M. Paulmichl, The molecular and functional interaction between ICLN and HSPC038 modulates the regulation of cell volume, The Journal of Biological Chemistry – JBC Papers in Press. Published on September 14, 2011 as Manuscript M111.260430.

S. Swaminathan, R. Cavalli, F. Trotta, P. Ferruti, E. Ranucci, I. Gerges, A. Manfredi, D. Marinotto, P. R. Vavia. In vitro release modulation and conformational stabilization of a model protein using swellable polyamidoamine nanosponges of β-cyclodextrin. Journal of Inclusion Phenomena and Macrocyclic Chemistry. 2010, 68 (1-2), pp 183-191.

L. Calucci, C. Forte, I. Gerges and E. Ranucci. Effect of pH on Water Proton NMR Relaxation in Agmatine-Containing Poly(amidoamine) Hydrogels. Langmuir, 2009, 25 (4), pp 2449–2455.

A. Tocchio, D. Horák, M. Babič, M. Trchová, M. Veverka, M. J. Beneš, M. Šlouf, A. Fojtík, Magnetic poly(glycidyl methacrylate) particles prepared in the presence of surface-modified γ-Fe2O3, Journal of Polymer Science Part A: Polymer Chemistry, 2009, 47(19), 4982–4994.

R. Gandini, S. Dossena, V. Vezzoli, M. Tamplenizza, E. Salvioni, M. Ritter, M. Paulmichl, J. Furst, LSm4 associates with the plasma membrane and acts as a Co-factor in cell volume regulation.Cell Physiol Biochem. 2008;22(5-6):579-90. Epub 2008 Dec 9.

F. Martello, J.F.J. Engbersen, P. Ferruti, Hyperbranched poly(amidoamine)s containing disulfide linkages in the main chain for DNA transfection, Journal of Controlled Release, 2008, 132, 1–18.

E. Ranucci, P. Ferruti, R. Annunziata, I. Gerges, G. Spinelli. NMR Spectroscopy and MALDI-TOF MS Characterisation of End-Functionalised PVP Oligomers Prepared with Different Esters as Chain Transfer Agents. Macromolecular Bioscience, 2006, 6 (3), pp 216–227.